Automated analytical apparatus and method

专利名称：Automated analytical apparatus and method发明人：Cohen, Beri,Hedaya, Eddie,Leniart, Daniel

S.,Schwarzberg, Moshe,Svenjak, Dario

申请号：EP903073.9申请日：19900719公开号：EP04105A3公开日：19910807

专利附图：

摘要：An automated analytical apparatus by which homogeneous and heterogeneousanalyses can be performed concurrently and on a random access basis includes a circularreaction tray (3) supporting a multiplicity of peripherally arranged reaction cuvettes,

sample handling arrangement (4)for supporting samples to be analyzed and a reagenttray (73) supporting a plurality of liquid-reagent sources. The individual samples andliquid reagents are transferred, on a selective-random mode, by appropriate aspirating-dispensing apparatus (5,8) into reaction cuvettes on the reaction tray which aresuccessively positioned at sample and reagent addition stations. The reaction tray isrotated from the reagent addition station to allow mixing and incubation of the reactionmixture and to position each cuvette at an analysis station (11). In the case of

heterogeneous assays, magnetic particles are introduced into appropriate cuvettes at amagnetic particle suspension addition station. A particle wash station (9) is providedbetween the magnetic particle suspension addition station and the analysis station (11)whereat, after the reaction, the solid phase is washed in the reaction cuvette to removeunbound materials. Following such wash, substrate may be added (10) to the reactioncuvette for reaction with an enzyme solid phase and the magnetizable particles areresuspended. The reaction cuvette is then advanced to the analysis station, where thesolid phase is withdrawn from the optical path and the appropriate optical readout of theliquid phase is effected. In respect of both heterogeneous and homogeneous assays, therotational mode of the reaction tray is bidirectional, to provide multiple periodicreadouts of each cuvette, to obtain data which is processed to provide the rate of thereaction.

申请人：TECHNICON INSTRUMENTS CORPORATION,TRITON BIOSCIENCES INC.

地址：511 Benedict Avenue Tarrytown New York 10591 US,1501 Harbor Bay ParkwayAlameda, CA 94501 US

国籍：US,US

代理机构：Wain, Christopher Paul

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