FLUORESCENT DYES, METHODS AND USES THEREOF

专利名称：FLUORESCENT DYES, METHODS AND USES

THEREOF

发明人：Helen E. Blackwell,Matthew D. Bowman申请号：US11559510申请日：20061114

公开号：US20070128658A1公开日：20070607

专利附图：

摘要：The present invention provides a method for identifying and characterizingcandidate fluorescent molecules. This method involves the generation of spatiallyaddressed arrays of heterocyclic compounds which are candidate fluorescent molecules.The spatially addressed array can be used to identify fluorescent molecules among thecandidate molecules. The spatially addressed array can be used to determine the opticalcharacteristics of one more candidate molecules. The invention also provides methodsfor making such arrays of heterocyclic compounds. In a specific embodiment, syntheticmethods are provided for synthesis of triarylpyridines, particularly unsymmetrictriarylpyridines. n preferred embodiments, the present invention provides novelheterocyclic fluorescent compounds having deazalumazine, cyanopyridine or pyrimidinecores. Heterocyclic fluorescent compounds of this invention are useful as dyes to labelmolecules such as nucleic acids, peptides and proteins, and particularly antibodies. In

other embodiments, the novel heterocyclic fluorescent compounds are useful as dyes tolabel cellular compartments and organelles. The novel heterocyclic fluorescentcompounds can also be used as sensors or indicators of specific metal ions, chemicalwarfare agents and pH.

申请人：Helen E. Blackwell,Matthew D. Bowman

地址：Middleton WI 53562 US,Madison WI 53706 US

国籍：US,US

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