PROCESS FOR THE PREPARATION OF ESTETROL

专利名称：PROCESS FOR THE PREPARATION OF

ESTETROL

发明人：PLATTEEUW, Johannes Jan,COELINGH

BENNINK, Herman Jan Tijmen,DAMEN,Franciscus Wilhelmus Petrus,VAN VLIET,Michiel Christian Alexander

申请号：EP12742968.6申请日：20120718公开号：EP2734536A1公开日：20140528

摘要：The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3,15±,16±,17²-tetraol (estetrol), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, wherein A is a protecting group and B is €•Si(R 2 ) 3 .The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is a protecting group, via said silyl enol ether derivative.

申请人：Pantarhei Bioscience B.V.

地址：Boslaan 11 3701 CH Zeist NL

国籍：NL

代理机构：Nederlandsch Octrooibureau

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